Targeting of nanoparticles to tumor sites can be achieved by several general methods: passive, active, or through externally applied forces, as shown in Figure 1. With high surface area to volume ratios and unique physiochemical properties, the architecture of nanoparticles allows optimization for the delivery of various imaging and therapeutic agents. The integration of nanotechnology and targeted drug delivery has opened potential avenues to achieve this goal. Since Paul Ehrlich promoted the concept of a “magic bullet' in the early 1900s, researchers have attempted to develop targeted platforms that can distinguish between cancer cells and the trillions of healthy cells in the body, and deliver a therapeutic drug dose to cancer cells without harming healthy cells. Current treatment options, including surgery, radiotherapy, and chemotherapy, are invasive, painful, and often ineffective and imprecise, which result in acute and chronic side effects that negatively impact the patient's overall well-being. Despite recent advances in the fields of cancer diagnosis and therapy, the path to curative therapies remains littered with significant hurdles that must be overcome. Keywords: MRI-guided therapy, combination therapy, multimodal imaging, active targeting, magnetic targeting IntroductionĬancer is a leading cause of mortality, with 606,520 cancer-related deaths projected to occur in the United States in 2020. With a special focus on systems that have been tested in vivo, this review is an essential summary of the most advanced developments in this rapidly evolving field. dual magnetic-active targeting and nanoparticles carrying multiple ligands), and tumor microenvironment-responsive drug release ( e.g. combined T1-T2 imaging, triple and quadruple multimodal imaging), novel targeting strategies ( e.g. combined chemo-gene therapy), unique MRI-based imaging ( e.g. This review article presents a comprehensive assessment of nanotheranostic systems that combine MRI-based imaging (T1 MRI, T2 MRI, and multimodal imaging) with therapy (chemo-, thermal-, gene- and combination therapy), connecting a range of topics including hybrid treatment options ( e.g. Among the imaging modalities used, magnetic resonance imaging (MRI) provides high resolution imaging of structures deep within the body and, in combination with other imaging modalities, provides complementary diagnostic information for more accurate identification of tumor characteristics and precise guidance of anti-cancer therapy. A variety of multifunctional, cancer-targeted nanotheranostic systems that integrate therapy, imaging, and tumor targeting functionalities in a single platform have been developed to overcome the shortcomings of traditional drugs. File import instruction AbstractĬurrent cancer therapies, including chemotherapy and radiotherapy, are imprecise, non-specific, and are often administered at high dosages - resulting in side effects that severely impact the patient's overall well-being. Select the file that you have just downloaded and select import option Reference Manager (RIS). #Magnetic gold core shell nanoparticles price download#Available fromĬlick on Go to download the file. MRI-traceable theranostic nanoparticles for targeted cancer treatment.
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